I run PHD2 as my guiding program on a Toshiba Satellite Laptop, L505D. And my laptop is... gosh, 10-12 years old. Dual Core processer 2.20 Ghz, Windows 10, running 4.00 Gig of RAM, and a 64-bit operating system. Whew! Bla, bla, bla... But not the latest of the greatest computer, and doing a lot for what it is now days.
I use to have troubles with things, especially my main camera, dropping out and needing the USB plugged out and back in for the camera. A friend suggested I use a Powered USB Hub. Since doing that, there is not a "USB Bottleneck" slowing down anything, and plenty of power for everything USB.
I have come to having my images saved to the powered USB hub to a thumb drive. This was an experiment one evening and it has become wrote for me now. Keeps the lappy happy not straining for power or storage. And cured two of the problems right up. Not to mention my pictures are easily moved from one place to another.
My Laptop was running both some 32 bit, and 64 bit programs, and Windows 7. My desktop (tower) was running Windows 8.10, and 64 bit. When I was offered to upgrade to Windows 10, I did so with both, and settled on 64 bit operating for both. Essentially, I "groomed" both to be the same, for ease of working with both. 64 bit was backwards compatible to 32 bit, but sometimes 32 bit programs wouldn't run for me under the 64 bit. So when upgrading to Windows 10 I tried to eliminate the differences via the software differences. So far, so very good. (I also have both running the same programs for anything Astronomy related)
I chose THIS HUB for my needs because it operates at 12 VDC, and can be powered up with my battery or the mains power adapter it comes with. And for the particular way the leads plug into it so it could mesh with my wiring harness easily. Then there is only the one USB cable coming to my Laptop from it. USB3 is also backwards compatible with USB2 which seems to be so prevalent with Astro equipment still, so there you have it, being upgradable if/when you get a newer laptop.
I think that adding a Powered USB hub was probably the best thing since getting PHD2 and my guidance working to make things work smoothly. So maybe it isn't your Laptop as much as it is the USB struggling? But I don't think trying a Powered USB Hub can do you any harm. Other than the ding to the wallet for it.