My first relative success at this target.
Some dust mites show because the mount had good tracking and I used no darks nor flats. With my camera the cure should be quite simply to power cycle off/on so that auto-cleaning moves the dust elsewhere.
Capture: Olympus E-PL6 on Skywatcher 130PDS at 565mm/4.35 with SWCC and didymium filter on Omegon EQ-300 tracking RA
Exposure: 12 × 60s × 2500iso
Site: 50km from Paris (France), sky Bortle ~ 4
Processing: Regim 3.4, Fotoxx 12.01+