Hi Martin.
I've already posted a similar question with a screenshot of the error message on the Prism forum. I've yet to receive a response hence asking whether there are any other Prism users out there.
In the meantime, I've got Prism to recognise the imager and guider as Ascom devices and that has enabled me to link Prism to them. But for whatever reason, neither of the cameras can be identified as SX devices by the Prism 'native' driver for SX cameras without falling foul of the error message despite it showing as an option (alongside lots of other camera manufacturers!).
Based on using it in simulation mode, it's an incredible sophiticated and comprehensive piece of ap software. But if I can't get to a point where it can recognise my two cameras and for one to be defined as an imager and the other as a guider, it looks like I'll never be able to use it in anger.